As announced by Dan Philbrick, Autodesk's Civil 3D Software Development Manager, in the blog he shares with Dave Simeone, "The Dave and Dan Civil 3D Show" Autodesk has just released one new whitepaper and updated a previous whitepaper.
The new whitepaper is titled:
Best Practices for Working with Large Data Sets
The updated whitepaper is:
Civil 3D 2008 Project Management Using Autodesk Vault
Lastly, Dan mentions technical solution 1071001 that involves enabling Window to over-ride the 2GB limit for applications and allow Civil 3D to use 3GB of physical memory to improve performance.
All of this information is very useful and much appreciated. Thanks Autodesk.